Yes, the only 2 exceptions to the 2 barrel rule that I've seen would be 350 2 barrels with the big 2 barrel had a 3/8 line and some early 4 barrel 283's had a 5/16 line.
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1966 Strato Chief 2 door, 427 4 speed, 45,000 original miles
1966 Grande Parisienne, 396 1 of 23 factory air cars (now converted to a "factory" 4 speed)